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KMID : 0385220010110030024
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Korean Journal of Gerontology
2001 Volume.11 No. 3 p.24 ~ p.28
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Peroxynitrite and Hydroxyl Radical Scavenging Activity of Dihydroxybenzaldehydes
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Yang Young-Hwan
Kim You-Jung
Chung Hae-Yong
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Abstract
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Peroxynitrite and hydroxyl radical are potent oxidants that have a potentially causative effect on cancer and other deleterious pathogenesis of various diseases. Peroxynitrite is protonated at physiological pH to produce peroxynitrous acid, which is dissociated to nitrogen dioxide and hydroxyl radical. Thus, finding of appropriate scavengers for these potent oxidants is important task to understand the overall strategy of our body defense systems against oxidative stress. In the present experiments, derivatives of 3,4-dihydroxybenzaldehyde originated from a Chinese medical herb Salvia miltiorrhiza, were tested for the antioxidant scavenging effects. The results indicate that 3,4- and 2,3-dihydroxybenzaldehyde showed remarkable scavenging activity effects on peroxynitrite and hydroxyl radical. Structure-activity relationship was investigated. The requirement for the hydroxyl radical scarvenging activity is the presence and position of hydroxyl and aldehyde groups in the benzaldehyde structure. Furthermore, for peroxynitrite scavenging activity, ortho-hydroxyl groups seem to function as active site, while aldehyde group is not essential. We concluded that 3,4- or 2,3-dihydroxybenzaldehydes are potent scavengers of peroxynitrite as well as hydroxyl radicals.
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KEYWORD
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peroxynitrite, hydroxyl radicals, 3, 4-dihydroxybenzaldehyde, scavenging
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